Electrochemical Detector Packages

LC Epsilon


BASi® offers the LC Epsilon electrochemical detector package; which is ideal for both HPLC and UPLC applications. The LC Epsilon is suitable for non-regulator uses, but is also easily validated if you are working in a GxP regulated lab. BASi® can perform your IQ/OQ.

BASi® developed the first commercial electrochemical detector in 1974. All others are imitators. Since then, through research and development, BASi® electrochemical detectors offer greatly enhanced capabilities and performance. We are now offering our 7th generation electrochemical detectors. The digital LC Epsilon electrochemical detector is PC controlled, and comes with instrument control and data acquisition software.

An electrochemical detector package build upon either the LC Epsilon electrochemical detector with an electrochemical flow cell, an (optional) injection valve, and a CC-5 Compartment. Electrochemical cells are very sensitive to stray electrical currents.  For that reason, the CC-5 Compartment serves as a Faraday cage to shield the electrochemical cell from such currents. For optimal isolation, the injection valve, the chromatography column and the electrochemical detection cell are contained within the CC-5 Compartment. BASi® electrochemical detector packages can be used with a standard bore or microbore analytical column. Several options allow you to optimize the system to your specific application. Further, if your application changes, BASi® electrochemical detector systems have the flexibility to change with you.

LC epsilon

Epsilon LC-EC Detector Package
Shown with Epsilon, CC-5 EC Cell Compartment (may contain for example:  injector, electrochemical flow cell, chromatography column, and LC-23C Column Heater), and (optional) LC-22C Column Temperature Controller


The CC-5 Compartment can be configured for standard or microbore chromatography. Temperature fluctuations can change the elution time from a chromatography column. The standard bore CC-5 configuration (right) is shown with a column heater to maintain constant column temperature. Actively controlling column temperature can also provide you with an additional dimension of control over peak elution timing during method development. Also shown with electrochemical flow cell, standard bore column in (optional) LC-23C Column Heater and sample injector.

A microbore electrochemical detector package offers the greatest sensitivity. If you will be analyzing microdialysis samples (for example), you will want a microbore package. In a microbore system, to minimize sample dispersion, the microbore LC column should be directly connected into the outlet port of the sample injector. The other end of the column is connected directly to the electrochemical flow cell.


Microbore column plumbed to maximize sensitivity
Microbore Column

Standard Rheodyne sample injectors are grounded. Connecting the electrochemical detector cell to standard injectors via the metallic column would short out the electrochemical cell. To avoid that, we ship microbore configured systems with a custom Rheodyne injection valve equipped with a custom Rheodyne PEEK back plate. The PEEK insulates the EC cell from the valve™s connection to ground. Also, the ports in this valve are designed to minimize sample peak dispersion. While optimized for microbore, this valve can also be used for standard bore chromatography. Either injection valve is mounted in the CC-5 Compartment. The CC-5e also serves as a spill tray in the event of fluid leaks.

Electrochemical Detector Details

If you have any questions or would like to discuss which BASi® electrochemical detector configurations will be optimal for your application, please call or email.

View a refresher on the Principles of HPLC Electrochemical Detection.