Open flow microperfusion (OFM) is a novel, tissue-specific sampling technique that builds on the strengths of minimally invasive, interstitial sampling methods such as microdialysis (MD). OFM uses patented membrane-free probes with macroscopic openings which create an exchange area for the probe’s perfusate and the surrounding interstitial fluid (ISF). OFM samples represent a diluted, but unfiltered, ISF and thus contain all substances regardless of their physico-chemical properties (e.g. lipophilicity) or molecular size (e.g. antibodies, nanocarriers). Continuous OFM sampling provides dynamic substance profiles and absolute substance quantification in the investigated target tissues and is currently available for brain, skin, and adipose tissue.
OFM is a valuable tool in neuroscience, dermatology, oncology, biomarker research and PK-PD studies.
Minimally invasive open flow microperfusion (OFM) can be used …
OFM derives better data and drives better decisions
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Read OFM Press Release.